Academic Report: Mechanical Milieu of Cells in Engineered Tissue Constructs
Speaker:Professor Karen C. Yan, Department of Mechanical and Biomedical Engineering, College of New Jersey
Time: 2017.8.4 09:30-11:00
Location: Meeting Room 103 in Teaching Building 1 in Yuquan
Abstract:
With the advance of 3D printing technology, engineered tissue constructs can be fabricated by combining cells, biomaterials and biologically active molecules to mimic nature tissues more precisely. Cells in engineered tissue constructs often experience mechanical forces/stimuli during the fabrication and maturation processes, and under in vivo conditions. It is well known that these mechanical forces/stimuli induce cellular responses and in turn affect cell viability, proliferation, and differentiation. Hence, it is critical to understand the mechanical microenvironment of cells in engineered tissue constructs during different processes. In this talk, I will introduce a multi-scale modeling and analysis method for determining the microenvironment that cells experience due to mechanical forces and predicting cell viability. Three case studies will be presented, including 3D printed tissue constructs under static compressive loading and cyclic stretching, and forces experienced by cells during the extruding based process. Remaining challenges will also be discussed.
Brief Bio:
Dr. Karen C. Yan is currently a Professor in Mechanical and Biomedical Engineering at the College of New Jersey. She received her B.S. degree in Mechanical Engineering from University of Science and Technology of China, M.S. and Ph.D. degrees in Mechanical Engineering from Drexel University. Her research ranges from biomaterials, 3D bioprinting, fabrication of microfluidic devices, and composite materials. She has published numerous peer-reviewed journal articles and conferences papers. Dr. Yan is actively involved in American Society of Mechanical Engineers, and currently serves as Chair of Composites and Heterogeneous Materials Technical Committee in Materials Division of American Society of Mechanical Engineers.